Our laboratory focuses on how brain cells adapt and survive – studying neuronal plasticity and nerve cell protection in the context of disease. The laboratory takes a multidisciplinary, multi-level approach – from molecules to whole organisms – to investigate brain disorders such as autism, schizophrenia, and Alzheimer’s disease. It employs a broad range of techniques (molecular genetics, biochemistry, cell imaging, bioinformatics, and animal behavior studies) to explore how genetic mutations and cellular pathways impact learning, memory, and social behavior.

Among the laboratory’s key achievements is the discovery of the activity-dependent neuroprotective protein (ADNP), an essential protein for brain development found to be mutated in an autism-related disability syndrome. Furthermore, the laboratory discovered and is developing its peptide derivative, NAP (davunetide), as a potential therapeutic now advancing to phase 3 clinical trials. Through these efforts, the laboratory ultimately aims to translate its scientific discoveries into novel therapies for currently incurable neurological conditions.